OUR PEOPLE
The team
Shev Acharya
PhD student
Shev is a first-year PhD student, supervised by Dr Mikhail Spivakov (MRC LMS) and co-supervised by Dr Nathan Skene (Imperial DRI). Her project focuses on using network approaches and single-cell multiomics to interpret disease-associated variation. Shev’s academic foundation was laid with a BSc in Biomedical Sciences from Brunel University London, followed by an MSc in Pharmacology at King’s College London. Solidified through her education, she firmly believes that a deep understanding of DNA and its intricacies is essential for the development of novel and more effective drugs. Outside the lab, Shev enjoys movies and thrilling adventures.
Surya Koturan
Postdoc
Surya studied Biotechnology at Vellore Institute of Technology in India and continued to do an MSc in Human Molecular Genetics at Imperial College London. She did her PhD in Immunology at Institut Pasteur in Paris, where she worked on how genetic variants influence immune cell function in Spondyloarthritis. She then worked as a postdoctoral researcher at the Department of Oncology at University of Oxford, where she studied the role of G-protein coupled receptor genes in immune cells in the context of melanoma using single-cell RNA-seq. Surya’s current research in FGC group focuses on investigating the temporal dynamics of gene regulatory networks upon stimulus response in the innate immune system using single-cell multiomics.
Outside the lab Surya enjoys learning languages, hiking and experimenting with new recipes.
Jela Guo
BSc Student
Jela is a third-year undergraduate student studying medical bioscience course at Imperial. She has joined Mikhail’s lab to pursue her third year project investigating gene regulatory networks upon stimuli in monocytes using single-cell multiomics under the day-to-day supervision by Surya.
jela.guo21@imperial.ac.uk
Isabella Savin
BSc Student
Isabella is a Medical Biosciences BSc student at Imperial College London who has joined the Functional Gene Control group for her final year project. Isabella built up a keen interest in molecular epigenetics before starting her undergraduate degree, and her project (under the day-to-day supervision of Marina Nocente) focuses on using inducible CRISPR approaches in human pluripotent stem cells to investigate changes in chromosomal conformation and gene expression upon activation of specific enhancers. Outside the lab, Isabella enjoys cooking, writing poems, and performing in musicals.
Marina Nocente
Postdoc
During her studies at Paris-Saclay university, Marina was particularly interested in molecular biology, genetics and epigenomics. She completed her PhD at the Institute for Integrative Biology of the Cell (Gif-sur-Yvette, France), focusing on chromatin remodelers, and nucleosomal and subnucleosomal organisation of mouse genome. In the FGC group, she investigates the interplay between physical enhancer-promoter connectivity and function using high-throughput chromosomal conformation and CRISPR activation approaches in human iPS cells. In her free time, Marina enjoys ballet and discovering green spaces in London.
Pavel Artemov
PhD student
Pavel is a PhD candidate studying how cells rewire their gene regulatory networks to acquire resistance to targeted cancer drugs, focusing on BTK inhibitors in lymphoma treatment. In the lab, Pavel has co-supervised several summer interns and masters students – Ho Kai, Ashid, Jess, Joe and Namrata. Pavel previously did his MSci in Systems Biology and BA in Biochemistry at Corpus Christi College, University of Cambridge. Outside of the lab, Pavel enjoys a good movie, reading and playing 5 a side.
Luminita Ruje
PhD student
Lumi combines computational and wet-lab approaches to study the signalling and epigenetic heterogeneity of drug-resistant cancer cells. She graduated in Genetics from the University of Essex, where the she also worked as a computational specialist assessing epigenetic changes in cancer. Lumi also had a placement with Vertex Pharmaceuticals, where she used single-cell RNA-seq data to explore changes in cell-to-cell communication in ulcerative colitis. Outside of work, Lumi enjoys swimming, foraging and reading about nature.
Mikhail Spivakov
Group Leader
Mikhail is interested in how enhancers regulate gene expression, and how their function is modified by natural genetic variation. He is also interested in keeping the team happy and motivated.
OUR PEOPLE
Our alumni
Namrata Gogineni
MSc student
Namrata was working with Pavel on computational methods to predict the effect of enhancers on gene expression. She moved on to continue her Masters course.
Monica Della Rosa
PhD student
Monica was investigating the logic of gene regulation by enhancer elements in human pluripotent cells. She moved on to start a Bioinformatician position at Cyted.
Lina Dobnikar
PhD student
Lina led single-cell genomics analysis of vascular lineage plasticity. She has moved on to a Staff Bioinformatician position at CeMM, Vienna.
Mirko Celii
Visting postdoc
Mirko was visiting from Valerio Orlando’s lab to study the nuclear dynamics of muscle cell differentiation.
Hashem Koohy
Postdoc
(jointly with Nuclear Dynamics ISP)
Hashem worked on the cis-regulatory features of V(D)J recombination. He moved to start his own group at Oxford University’s Radcliffe Department of Medicine.
Sunghee Park
Visiting professor
Sunghee is now back at Soongsil University in Seoul.
Margaret Lister
MSc student
Margaret used CRISPR targeting to study the relationship between enhancer activity, connectivity and gene expression. She moved on to do a PhD at Oxford University.
Valeriya Malysheva
Postdoc
Valeriya used a combination of wet-lab and computational approaches to study promoter-enhancer interactions and stimulus response in innate immune cells. She moved on to start her own lab at VIB Institute of Molecular Neurology, Antwerp.
Michiel Thiecke
PhD student
Michiel worked on the effects of cohesin and CTCF on promoter-enhancer interactions. He has moved on to a Senior Computational Biologist position at Enhanc3D Genomics Ltd.
Carmen Petitjean
BSc student
Carmen did her 3rd year project with us, working with Valeriya on the enhancer-promoter interaction detection.
Jonathan Cairns
Postdoc
(jointly with Peter Fraser group at Nuclear Dynamics ISP)
Jonathan worked on the Chicago pipeline. He moved to become a Senior Research Statistician at AstraZeneca.
Phoebe Oldach
MPhil student
Phoebe moved back to the US, and then again on the island to do a PhD at Oxford.
Manuela Zanda
Visiting postdoc
Manuela was staying with us in 2013 as part of our collaboration with her main lab at UCL led by Vincent Plagnol. Manuela has moved on to become a data scientist at ARM.
Jess James
Masters student
Jess was working with Pavel on gene regulatory networks underlying cancer drug resistance. She moved on to continue her Masters course at Imperial.
Emma Yang
MSc student
Emma did her Masters project in our group, looking at the molecular underpinnings of immune traits, including COVID susceptibility. She moved on to start her PhD studies in Edinburgh after a gap year.
Joseph Ellaway
MSc student
Joseph worked with Pavel on the computational methods to predict the effect of enhancers on gene expression (a project later picked up by Namrata). He moved on to continue his Masters course.
Will Orchard
Visting student
Will worked on the chicdiff pipeline before going back to continue his studies at Cambridge University.
Paula Freire Pritchett
Postdoc
Paula worked on the Chicago pipeline and the rewiring of enhancer-promoter interactions upon human ES cell differentiation. She moved to MRC LMB as a founding member of the core bioinformatics facility.
Qian Gao
Postdoc
(jointly with Jon Houseley group at Babraham)
Qian joined Adaptimmune as a bioinformatics scientist.
Ho Kai Li
MSc student
Ho Kai studied the response of cancer cells to targeted therapies.
Helen Ray-Jones
Postdoc
Helen used population genetics approaches to understand the logic of enhancer-promoter interactions. She has moved on to join Valeriya’s new lab at VIB Antwerp as a Senior Postdoc.
Nicole Wong
Masters student
Nicole was investigating gene regulatory networks underlying stimulus response of innate immune cells. She moved on to continue her Masters course at Imperial
Vanessa Tan
BSc student
Vanessa worked with Helen on the chromatin properties of genetic variants and is now back home in Singapore to continue her education.
Anna Litovskikh
BSc student
Anna did her summer internship and 3rd year project with us, working with Helen to study the chromatin properties of genetic variants.
Erin Oerton
Rotation PhD student
Erin moved on to do a PhD in Andreas Bender’s group at Cambridge University’s Department of Chemistry
Jo Mitchelmore
PhD student
Jo worked on the transcriptional effects of variation in transcription factor binding. She has moved on to a Data Scientist position at Novartis Institutes of Biomedical Research in Basel.
Pawel Bednarz
Visiting student
Pawel moved back to Poland to finish his PhD at Warsaw University.
Interested in studying gene regulation?
Why not join us? We are always happy to hear from enthusiastic people interested in studying gene regulation