I use a combination of wet-lab and computational approaches to study promoter-enhancer interactions in the context of gene regulatory networks.
I use population genetics approaches to understand the logic of enhancer-promoter interactions.
Monica is investigating the logic of gene regulation by enhancer elements in human pluripotent cells.
Joseph is using computational methods to predict the effect of enhancers on gene expression.
Vanessa is working with Helen on the chromatin properties of genetic variants.
I am interested in the logic and robustness of gene regulation. I am also interested in keeping the group happy and motivated.
More about Mikhail
Michiel worked on the effects of cohesin and CTCF on promoter-enhancer interactions. He has moved on to a Senior Computational Biologist position at Enhanc3D Genomics Ltd.
Lina led single-cell genomics analysis of vascular lineage plasticity. She has moved on to a Staff Bioinformatician position at CeMM, Vienna
Emma did her Masters project in our group, looking at the molecular underpinnings of immune traits, including COVID susceptibility.
Anna did her summer internship and 3rd year project with us, working with Helen to study the chromatin properties of genetic variants.
Carmen did her 3rd year project with us, working with Valeriya on the enhancer-promoter interaction detection.
Mirko was visiting from Valerio Orlando’s lab to study the nuclear dynamics of muscle cell differentiation.
Will worked on the chicdiff pipeline before going back to continue his studies at Cambridge University.
Jo worked on the transcriptional effects of variation in transcription factor binding. She has moved on to a Data Scientist position at Novartis Institutes of Biomedical Research in Basel.
Jonathan worked on the Chicago pipeline. He moved to become a Senior Research Statistician at AstraZeneca.
Hashem worked on the cis-regulatory features of V(D)J recombination. He moved to start his own group at Oxford University’s Radcliffe Department of Medicine.
Paula worked on the Chicago pipeline and the rewiring of enhancer-promoter interactions upon human ES cell differentiation. She moved to MRC LMB as a founding member of the core bioinformatics facility.
Pawel moved back to Poland to finish his PhD at Warsaw University.
Phoebe moved back to the US, and then again on the island to do a PhD at Oxford.
Sunghee is now back at Soongsil University in Seoul.
Qian joined Adaptimmune as a bioinformatics scientist.
Erin moved on to do a PhD in Andreas Bender’s group at Cambridge University’s Department of Chemistry
Manuela was staying with us in 2013 as part of our collaboration with her main lab at UCL led by Vincent Plagnol. Manuela has moved on to become a data scientist at ARM.