We aim to decipher the ground rules of gene regulation and establish their functional interplay in biological phenomena involving global changes in phenotype, such as in cell differentiation and activation. Our current focus is on the role of non-coding DNA elements such as enhancers in integrating and transmitting gene regulatory information.
MRC LMS is part of Imperial College’s Institute of Clinical Sciences (ICS) and is based on the Hammersmith Hospital campus, opening up many exciting opportunities for collaborations across disciplines.
We have released Chicdiff, an R package for differential analysis of Capture Hi-C data. Joint work by the power team: Jo…
Our study of vascular smooth muscle cell heterogeneity using single-cell transcriptomics and lineage tracing is finally…