We aim to decipher the ground rules of gene regulation and establish their functional interplay in biological phenomena involving global changes in phenotype, such as in cell differentiation and activation. Our current focus is on the role of non-coding DNA elements such as enhancers in integrating and transmitting gene regulatory information.
MRC LMS is part of Imperial College’s Institute of Clinical Sciences (ICS) and is based on the Hammersmith Hospital campus, opening up many exciting opportunities for collaborations across disciplines.
Monica’s and Mikhail’s News&Views article on two silencer papers is out in Nature Genetics. It was a very timely commiss…
Michiel’s preprint on the effects of cohesin depletion on rewiring of promoter-enhancer interactions and nascent transcr…