Enhanc3D Genomics and our group contribute to COVID-19 GWAS interpretation

In collaboration with Enhanc3D Genomics Ltd, we have linked non-coding GWAS SNPs associated with COVID-19 susceptibility and severity with their putative target gene based on 3D chromosomal conformation in blood cells.

For this analysis, we have used the COGS approach and Promoter Capture Hi-C data from our earlier study (Javierre et al., Cell 2016). The GWAS data are coming from the COVID-19 Host Genetics Initiative that we have joined for this task.

Our data are currently available at https://osf.io/k2mxe/ and will evolve with the next releases of the GWAS meta-analysis dataset. Our results will also be posted on the www.covid19hg.org website in due course.

Posted in: Uncategorized

Leave a Comment (0) →

Michiel’s preprint is out!

Michiel’s preprint on the effects of cohesin depletion on rewiring of promoter-enhancer interactions and nascent transcription is out!

https://doi.org/10.1101/2020.02.10.941989

A fruitful collaboration with Gordana Wutz and Wen Tang at Jan-Michael Peters’s lab at the IMP, Matthias Muhar at the IMP’s Zuber lab, and Stefan Schoenfelder and Peter Fraser at Babraham.

Now fingers crossed for the story’s smooth sailing to a journal…

Posted in: Uncategorized

Leave a Comment (0) →

Two new preprints

Today sees the publication of not just one, but two preprints from our lab and our close collaborators.

The first preprint is work led by Jo Mitchelmore (our group’s first ever PhD student, now at Novartis), in which she has used changes in transcription factor binding affinity at promoter-connected regulatory regions as predictor variables to detect eQTLs. Using this method, she’s uncovered hundreds of novel associations – and a bunch of epromoters, regions that function both as distal enhancers and promoters of other genes. Great collaboration with Chris Wallace and her postdoc Stasiya Grinberg.

Posted in: Uncategorized

Leave a Comment (0) →
Page 1 of 5 12345