Our recent paper on linking GWAS SNPs to target genes using Promoter Capture Hi-C has made the (local) news. Watch Chris Wallace and Mikhail explain 3D regulatory architecture to Cambridge TV’s Karen Thomas here.
This paper, published in today’s issue of Cell, presents a high-resolution analysis of interactions involving nearly all annotated promoters in 17 human primary blood cell types. Integrating promoter interaction maps with chromatin and population genetics data, we link enhancers and promoters, and disease-associated variants with their putative target genes. The paper is the result of a large multi-centre collaboration of Peter Fraser’s and our labs at Babraham Institute with fantastic colleagues and friends from other Cambridge centres. It’s been a hugely productive and exciting collaboration, which will hopefully continue beyond this project.
Paper (open access): http://www.cell.com/cell/fulltext/S0092-8674(16)31322-8.
A minireview presenting this paper in the same issue of Cell: http://www.cell.com/cell/fulltext/S0092-8674(16)31519-7 (Open Access).
Press release: http://www.babraham.ac.uk/news/2016/11/researchers-identify-missing-links-that-connect-human-dna-variation-with-disease
We are saying goodbye to the first brave person who joined Mikhail’s group when it was starting from scratch. Paula is moving several miles up the road to MRC LMB – to work on establishing a core bioinformatics service there. We are very sorry Paula is leaving us, but congratulate her on securing a job at such a fantastic place.
This year’s group retreat started with science brainstorming at the famous Eagle pub (which, bizarrely, opens for business at 8am). We then went over to Letchworth for an hour of laser tag! Turns out shooting at your colleagues is a lot of fun – especially when they don’t feel anything (unlike in paintball or in the more extreme version of laser tag involving electric shocks)…
The CHiCAGO paper led by Jonathan and Paula is finally out: http://www.genomebiology.com/2016/17/1/127. We released the manuscript as a preprint first, and it was already widely read and cited in this capacity. However, it’s still great to see our story formally published!
Congratulations to Hashem and everyone at the Corcoran lab, particularly Daniel Bolland who led this work jointly with Hashem!
This has been a productive and enjoyable collaboration, which now continues to address exciting follow-up questions.
The Chicago and PCHiCdata R packages are now part of the new Bioconductor release (3.3).
Their stable versions are now available here:
The chicagoTools scripts are not part of Bioconductor and will continue to be available from our Bitbucket repository:
As Bioconductor releases only happen twice a year, the Bitbucket repository will also continue to host the most recent versions of the R packages.
We welcome Lina Dobnikar from the Cambridge BBSRC DTP PhD programme for her rotation project in the lab. Lina will be using single-cell RNA-seq data analyses to characterise the vascular smooth muscle cell niche.
Michiel Thiecke is joining the group as an MRC-funded PhD student. Michiel has a Masters degree in bioinformatics and an impressive number of research internships all over the world under his belt. Welcome!