Archive for Uncategorized

Our guide to Capture Hi-C analysis is published

Our invited paper “Detecting chromosomal interactions in Capture Hi-C data with CHiCAGO and companion tools” is finally out at Nature Protocols (after 3 months in typesetting)!

Led by Paula (one of the lead authors of the original Chicago), Helen and Lera (postdocs in the lab), with invaluable contributions from other present and former lab members and collaborators.

For context, see also this Q&A on our institute’s website.

Posted in: Uncategorized

Leave a Comment (0) →

Joe joins the lab

Joe Ellaway has joined the lab for his (fully remote) MSc project in bioinformatics. He will be working on the computational prediction of enhancer-promoter contacts capitalising on existing models and Capture Hi-C data. Welcome Joe – sorry we don’t have a chance to meet you offline!

Posted in: Uncategorized

Leave a Comment (0) →

Enhanc3D Genomics and our group contribute to COVID-19 GWAS interpretation

In collaboration with Enhanc3D Genomics Ltd, we have linked non-coding GWAS SNPs associated with COVID-19 susceptibility and severity with their putative target gene based on 3D chromosomal conformation in blood cells.

For this analysis, we have used the COGS approach and Promoter Capture Hi-C data from our earlier study (Javierre et al., Cell 2016). The GWAS data are coming from the COVID-19 Host Genetics Initiative that we have joined for this task.

Our data are currently available at https://osf.io/k2mxe/ and will evolve with the next releases of the GWAS meta-analysis dataset. Our results will also be posted on the www.covid19hg.org website in due course.

Posted in: Uncategorized

Leave a Comment (0) →
Page 1 of 5 12345