Lera’s and Helen’s preprint is out!
Lera’s and Helen’s preprint describing a high-resolution promoter interaction profiling of a rare cell type, Type 3 Innate Lymphoid cells is out! In this collaborative project with labs in Cambridge and Ohio, we have taken advantage of these data to link GWAS variants associated with Crohn’s disease with target genes. Surprisingly, one of the prioritised genes, CLN3, is a causal gene for a rare neurodegenerative disorder Batten disease. With our collaborators in the US, we have then used a CLN3 mutant mouse model to show that this gene affects the immune function of Innate Lymphoid cells. We are very excited about this study!